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KMID : 0363320190400040709
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Journal of Korean Oriental Internal Medicine
2019 Volume.40 No. 4 p.709 ~ p.722
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Traditional Korean Medicine for Non-Small Cell Lung Cancer Patient Undergoing Pembrolizumab Immunotherapy: A Case Report
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Shim So-Hyun
Seo Hee-Jeong
Seo Hyung-Bum
Cho Im-Hak
Lee Chan
Kim So-Yeon
Han Chang-Woo
Park Seong-Ha
Yun Young-Ju
Lee In
Kwon Jung-Nam
Hong Jin-Woo
Choi Jun-Yong
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Abstract
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Objective: The purpose of this study was to report the effect of traditional Korean medicine (TKM) in alleviating the side effects of lung cancer patient undergoing immunotherapy.
Method: A 43-year-old man, who was diagnosed with non-small cell lung cancer, received pembrolizumab treatments. The patient was treated with acupuncture and herbal medicine (Geoeoyangpye-tang) to control various uncomfortable symptoms. The degree of pain was measured by the numeric rating scale (NRS). The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Core 30 (EORTC QLQ-C30) and the EORTC 13-item lung cancer-specific module (EORTC LC-13 questionnaire) were used to assess the change in the quality of life.
Results: After the TKM treatment, the flank pain and arthralgia based on the NRS were significantly improved. Various uncomfortable symptoms such as fatigue, dyspnea, insomnia, and loss of appetite were also significantly improved, based on the EORTC QLQ-C30 and EORTC QLQ-LC13. The size of the primary tumor was decreased during treatment. The disease status was stable radiologically after two months from discharge.
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KEYWORD
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non-small cell lung carcinoma, immune checkpoint inhibitor, PD-1 inhibitor, pembrolizumab, traditional Korean medicine, case report
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